A broad-spectrum antibiotic. It has an antibacterial, bactericidal effect.
White/off-white, oval, film-coated tablets containing amoxicillin trihydrate equivalent to 875 mg amoxicillin and potassium clavulanate equivalent to 125 mg clavulanic acid.
Synonyms: Co-Amoxiclav (UK), Clavulin (CA)
Augmentin is a combined antibiotic containing amoxicillin and clavulanic acid, with a wide spectrum of bactericidal action, resistant to beta-lactamase.
Antibacterial drugs for systemic use. Penicillins in combination with beta-lactamase inhibitors. Clavulanic acid + amoxicillin.
The presence of clavulanic acid in Augmentin protects amoxicillin from destruction by enzymes - beta-lactamases, which allows you to expand the antibacterial spectrum of amoxicillin.
Formal recommendations for the appropriate use of antibacterial agents should be taken into account.
Side effects observed in clinical trials and in the post-marketing period are presented below and are listed depending on the anatomical and physiological classification and frequency of occurrence.
Nausea is more common when using high doses of the drug. To reduce the degree of manifestation, it is recommended to take a suspension at the beginning of a meal.
Both active substances - amoxicillin and clavulanic acid - are quickly and completely absorbed from the gastrointestinal tract after oral administration. The absorption of active substances is optimal in case of taking the drug at the beginning of a meal.The drug is taken orally.
The dosage regimen is set individually depending on the age, body weight, kidney function of the patient, as well as the severity of the infection.
For optimal absorption and reduction of possible side effects from the digestive system, Augmentin® is recommended to be taken at the beginning of a meal.
The minimum course of antibiotic therapy is 5 days.
Treatment should not continue for more than 14 days without a review of the clinical situation.
It must be remembered that 2 tablets Augmentin 250 mg + 125 mg are not equivalent to 1 tablet Augmentin 500 mg + 125 mg.
Adults and children 12 years of age and older or weighing 40 kg or more.
One tablet 250 mg + 125 mg three times a day for infections of mild to moderate severity. In severe infections (including chronic and recurrent urinary tract infections, chronic and recurrent lower respiratory infections), other dosages are recommended.
One tablet of 500 mg + 125 mg three times a day.
One tablet of 875 mg + 125 mg twice a day.
Symptoms: gastrointestinal symptoms and water-electrolyte imbalance may occur. Amoxicillin crystalluria is described, in some cases leading to the development of renal failure. Convulsions may occur in patients with impaired renal function, as well as in those who receive high doses of the drug.
Treatment: gastrointestinal symptoms - symptomatic therapy, paying particular attention to normalizing the water-electrolyte balance. In case of an overdose, amoxicillin and clavulanic acid can be removed from the bloodstream by hemodialysis.