Amoxicillin & Clavulanate film-coated tablets

Buy Amoxicillin / Clavulanate tablets online

  • Active Ingredients: Amoxicillin, Clavulanate
  • Dosage: 875/125mg, 750/250mg, 500/125mg, 250/125mg

A broad-spectrum antibiotic. It has an antibacterial, bactericidal effect.

Package: Seven tablets in a blister of three-layer film and aluminum foil. Two blisters with instructions for use in a cardboard box.

Synonyms: Co-Amoxiclav (UK), Clavulin (CA)

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Common about

Amoxicillin and clavulanate potassium is used to treat many different infections caused by bacteria, such as , pneumonia, ear infections, bronchitis, urinary tract infections, and infections of the skin. Active ingredients: Amoxicillin 250 mg / 500 mg / 875 mg (as amoxicillin trihydrate 286.70 mg / 573.40 mg / 1003.44 mg). Clavulanic acid 125 mg (as potassium clavulanate 277.77 mg)

The presence of clavulanic acid protects amoxicillin from destruction by enzymes - beta-lactamases, which makes it possible to expand the antibacterial spectrum of amoxicillin.

Indications to use

  • infections of the upper respiratory tract (including ENT organs): acute and chronic sinusitis, acute and chronic otitis media, retropharyngeal abscess, tonsillitis, pharyngitis;
  • infections of the lower respiratory tract: acute bronchitis with bacterial superinfection, chronic bronchitis, pneumonia;
  • infections of the genitourinary system: pyelonephritis, pyelitis, cystitis, urethritis, prostatitis, chancre, gonorrhea;
  • infections in gynecology: cervicitis, salpingitis, salpingo-oophoritis, tubo-ovarian abscess, endometritis, bacterial vaginitis, septic abortion;
  • infections of the skin and soft tissues: erysipelas, impetigo, secondary-infected dermatoses, abscess, phlegmon, wound infection;
  • infections of bone and connective tissue;
  • biliary tract infections: cholecystitis, cholangitis;
  • odontogenic infections, post-surgical infections, prevention of infections caused by sensitive microorganisms, in the surgical treatment of pathologies of the gastrointestinal tract;

How I take amoxicillin and clavulanate?

Both active ingredients, amoxicillin and clavulanic acid, are quickly and well absorbed when taken orally. Absorption of active ingredients is optimal if is taken at the beginning of a meal.

The dosage regimen is set individually depending on age, body weight, renal function, and the severity of the infection. Treatment should not be continued for more than 14 days without re-evaluating the patient's condition.

Dosage

Adults and children 12 years old and older or weighing 40 kg or more

One tablet 250 mg + 125 mg 3 times a day for infections of mild and moderate severity.

One tablet 500 mg + 125 mg 3 times a day or 1 tablet 875 mg + 125 mg 2 times a day for infections of moderate and severe severity.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

Amoxicillin and clavulanate potassium side effects

Often

  • candidiasis of the skin and mucous membranes
  • diarrhea, nausea, vomiting. (Nausea was most commonly associated with the use of high doses. If, after the start of taking the drug, there are undesirable reactions from the gastrointestinal tract, they can be eliminated if you take the drug Amoxicillin + Clavulanic acid at the beginning of a meal)

Infrequently

  • dizziness, headache;
  • reversible leukopenia (including neutropenia), reversible thrombocytopenia;

Very rarely

  • reversible agranulocytosis and reversible hemolytic anemia, prolongation of bleeding time and prothrombin time, anemia, eosinophilia, thrombocytosis;
  • reversible hyperactivity, seizures. Seizures can occur in patients with impaired renal function, as well as in those who receive high doses of the drug. Insomnia, agitation, anxiety, behavior change;

The listed signs and symptoms usually occur during or immediately after the end of therapy, but in some cases they may not appear for several weeks after the end of therapy. Adverse reactions are usually reversible. Adverse reactions from the liver can be severe, in extremely rare cases there have been reports of deaths. In almost all cases, these were patients with serious comorbidities or patients receiving simultaneously potentially hepatotoxic drugs.

Contraindications

  • History of hypersensitivity to amoxicillin, clavulanate, beta-lactam antibiotics (eg, penicillins, cephalosporins).
  • Previous episodes of jaundice or abnormal liver function when using a combination of amoxicillin with clavulanic acid in history
  • Children under 12 years of age or body weight less than 40 kg
  • Severe renal impairment

Before starting treatment with Amoxicillin clavulanate, it is necessary to collect a detailed history of previous hypersensitivity reactions to penicillins, cephalosporins or other substances that cause an allergic reaction in the patient.

Overdose

Symptoms: Gastrointestinal symptoms and water and electrolyte imbalance may occur.

Described amoxicillin crystalluria, in some cases leading to the development of renal failure.

Seizures may occur in patients with impaired renal function, as well as in those receiving high doses of the drug.

Treatment: symptomatic therapy, correction of water and electrolyte balance. Amoxicillin + clavulanate is removed from the blood by hemodialysis.

Warnings

Important! Do not use antibiotics in combination with alcohol

Since the combination of amoxicillin with clavulanic acid can cause dizziness, care should be taken when driving or other mechanisms.

Carefully: in patients with impaired liver function.

Amoxicillin and Clavulanic Acid: Uses, Dosage, Side Effects & Precautions